Acne – is one of the most common types of skin disorders. It happens when the tiny hair follicles get blocked with dead skin and lead to the production of sebum. And that, as a result, leads to pimples and breakouts called acne.
Inhibitory Effects of Bee Venom on Propionibacterium Acnes-Induced Inflammatory Skin Disease in an Animal Model Introduction
​           P. acnes (propionibacterium acnes), a type of skin acne, is one of the main contributing factors for the inflammatory module of acne. Prescription medicines meant for treating acne make use of a combination of different treatments. They include strong antibiotics that lead to side effects apart from their few positive antibacterial effects. Most commonly these medicines cause suppression of the host inflammatory responses.
Method: BV (purified bee venom) contains Apis mellifera, which is an integral part of the modern treatment regimes. It has also been used in traditional medicines to cure different illnesses and diseases. This study was conducted, with two different groups, to examine the therapeutic effect of bee venom against the p. acnes. First of all, the mice, of both groups were injected p. acnes intradermally to induce inflammatory skin disease in them. Later, only one group was administered bee venom to carry out a comparison.
After inducing the subject model mice with p. acne, bee venom was applied right at the same location where p. acne was given. According to histological observation, it was found that p. acne induction in the right ear leads to a visible increase in the population of infiltrated inflammatory cells. But after the treatment of bee venom, this specific reaction was controlled in the p. acne induced mice when compared with those mice, which were not given bee venom.
Expression levels of interleukin (IL) - 1β and tumor necrosis factor (TNF) α, were remarkably induced in bee venom treated mice when compared with those who were not treated. Furthermore, bee venom treatment tremendously prevented CD14 and TLR2 expression in the p. acne injected tissue. The binding activity of AP1 (activator protein) and NFκB (nuclear factor kβ) was also brought down after bee venom treatment.

Links:
https://pubmed.ncbi.nlm.nih.gov/25215662/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486007/
https://pubmed.ncbi.nlm.nih.gov/24063779/

Bee venom treatment for allergies
​​Categorically defining allergy, it is a chronic disease that can lead to different symptoms. Its symptoms can vary from one person to another and according to the season. Allergy is a Greek word, which means a reaction that has been altered. Defining furthermore, an allergen triggers an unnatural response of our immune system to fight the external elements. According to research, it has been found that there are more than 30 different hormones that lead to allergic reactions. Most prominent are leukotrienes, prostaglandins, and histamine. ​
Now, let's have a look at what allergy looks like. The common symptoms of allergy are skin swelling and redness, asthma, coughing, red eyes, nasal congestion, runny nose, and itching. Nearly 20% of the total population has some sort of allergic complaints and nearly 10% have asthma. Allergens – the allergic substances – responsible for triggering these symptoms are found everywhere around us. Like some food items, house molds, road contaminants, mites, pollen, aerosols, etc.

There are two categories of allergy: IgE-mediated allergy and non-IgE-mediated allergy. To treat allergy, most commonly, anti-histamines and steroids like cortisone are prescribed. To manage severe allergy, immunotherapy – in different doses – is also given to control the symptoms.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516920/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512747/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796962/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806845/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC507602/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659083/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078942/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647995/

Bee Venom Alopecia Areata
Alopecia Areata is an organ-specific autoimmune process, which destroys hair follicles. The exact causes of the occurrence of Alopecia Areata are still not known. It is commonly said that emotional stress or a certain infection triggers a loss of hair. It has been found that it especially affects people, belonging to the age bracket between 20 and 50 years of age. There is no gender discrimination or generalization; it can hit both men and women of that age group.

​In the beginning, bald spots start appearing that are not more than 2 cm or 3 cm in size, later the spots can grow into big patches within a few weeks or month. In some cases, these spots vanish themselves and then appear again. Nearly 90% of the people experience Alopecia Areata at some point, which doesn't lead to a complete hair loss. These are small bald spots that manifest periodically.
The therapeutic effect of bee venom in Alopecia
Having healthy hair plays an important role in defining a person's look. In the same manner, hair loss can negatively affect self-confidence and overall look. The most obvious reason for hair loss is defined as genetic predisposition. Several specialists also believe that stress can lead to hair loss in young men and women. Other than genetic predisposition and stress, certain scalp diseases can also lead to hair loss. A recent study acclaimed that nearly 74% of subjects showed symptoms of alopecia due to inflammatory disorders like contact and atopic dermatitis. And nearly 25.5% of cases showed signs of some sort of mental illness.

According to Vivo Study
The preventive effects of bee venom on patients having alopecia was investigated by Part et al. clinical examination was carried out by administering minoxidil (2%) or bee venom to the dorsal surface of the mice for exact 19 days. DEX (dexamethasone) was used to induce the catagen in mice.

It was found that bee venom resulted in the growth of hair in mice. This process was done by increasing KGF (keratinocyte growth factor) that helps stimulate follicular proliferation and decreasing 5α-reductase. What happened was that 5α-reductase helped, enzymatically catalyze the transformation of testosterone into DHT that possesses higher affinity against the androgen receptors. That eventually led to hair loss as the hair follicles started minimizing.

It is to be noted that dutasteride and finasteride, are two most commonly used agents for treating hair loss. As they are based on obstructing 5α-reductase, they can lead to severe complications including gynecomastia, depression and sexual dysfunction. As a result, the treatment is discontinued at one stage.

​In this clinical study, no cytotoxicity, irritation, erythema, and edema were observed after administering bee venom. So the results suggest that bee venom can be safely used to promote the growth of hair.

According to Vitro Study
The overall health of hair depends on the duration or cycle of the anagen phase. And at any time, hair that is in telogen, catagen and anagen phase accounts of 9%, 1%, and 90% respectively. For carrying out vitro studies, hDPCs DEX-stimulated human dermal papilla cells were used that showed bee venom helped upregulate growth factors that included IGF-1, VEGF, FGF2, and FGF7. Bee venom also elevates the proliferation of hDPCs that along with a rise in growth factors keeps hair in the anagen stage for an extended period.
Hence, hair growth is encouraged in hDPCs.

Without any doubt, bee venom possesses the potential to help contribute towards hair growth. It can be actively used to treat hair loss, as it controls the progression of the catagen phase and promotes hair growth factors.

Several studies were carried out apart from alopecia, to determine the effect of bee venom on different skin diseases. In the end, no serious effects were registered. But it cannot be deemed that bee venom is safe. As it can cause anaphylaxis even in those subjects, who have tested negative for the bee venom skin test. As anaphylaxis can surface in any sort of condition, it is advised to have an emergency kit by side to control its symptoms.

It is important to monitor the condition of a patient for nearly 30 minutes after administering bee venom. This period has been allotted in the light of a retrospective clinical study that suggested the meantime for the onset of anaphylaxis to be 21.75 minutes exactly after injecting bee venom therapy. In certain conditions, elevated levels of basal serum tryptase could also lead to the occurrence of anaphylaxis.

According to this statement, the physiological state of any specific body, while administering bee venom, plays an important role in determining the occurrence of anaphylaxis. Analyzing the level of safety of bee venom treatment is crucial for determining the appropriate value of bee venom required as a therapeutic agent. It is highly hoped that extensive clinical studies will be carried out in the future to prevent anaphylaxis from occurring after administering bee venom.

Links: https://www.researchgate.net/publication/307655743_A_Case_of_Alopecia_Areata_Treated_with_Bee_Venom_and_Carthami_Flos_Herbal_Acupuncture
https://pubmed.ncbi.nlm.nih.gov/27040904/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669657/
https://pubmed.ncbi.nlm.nih.gov/27040904/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669657/

ALS - Treatment with Bee Venom
What is ALS?
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that leads to the death of neurons in the brain stem, brain, and the spinal cord. It ultimately causes paralysis and loss of muscle mass. In several cases, it has been reported that this disease spreads to legs, arms and even the tongue.

​Researchers have found different theories that help explain the reasons behind the manifestation of ALS. It is suggested that structural changes of protein can lead to malfunctioning and death of nerve cells. Considerable research has been done in the field of ALS over the past 10 years. One of the most prominent is the European project that consists of 15,000 subjects of ALS. A research group from Umea University, having 500 Swedish ALS patients, will also become a part of this extensive project.
Photo: ALS.org​

​The most common type of ALS consists of, SOD1, a misfolded protein that accumulates within neuron transmitters. Researchers are focusing on the reasons behind this misfolding and how it spreads and affects the nervous system. The main focus of various research groups is to devise methods that can help deter the formation and production of SOD1. It is to be noted that a few types of ALS and FTD (boiler lobe dementia) nearly have the same disease process that affects different parts of the nervous system. According to the researchers – it is due to the reason that both diseases have the same genes. It still needs to be assessed that why some patients become a victim of FTD and others ALS.

Links:
https://pubmed.ncbi.nlm.nih.gov/21682930/
https://pubmed.ncbi.nlm.nih.gov/20950451/
https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-8-69.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166716/

Alzheimers treatment with bee venom
There are several people, who have a misconception that dementia is only linked with aging. But in reality, dementia has little to do with the natural process of aging. It is a debilitating, chronic and common disease. A subject of dementia is defined as someone: having a memory disorder accompanied by any sort of cognitive disorder. Difficulty to think or process certain languages or having impaired judgment is known as a cognitive disorder. There are three main groups termed as: secondary dementia, primary degenerative dementia, and vascular dementia disease.
 Alzheimer's is one of the most common types of dementia disease that covers nearly 70% of the cases. While vascular dementia is the second most common type of dementia disease that covers nearly 20% of the overall cases.
What happens in the patients of Alzheimer's is that; the nerve cells present in the brain start depleting and that leads to the general loss of memory. The abundance of protein cells in the brain causes this disease. Known as amyloid plaques, they are composed of fibrils – lengthy strands of beta-amyloid protein.
​           ​The scientific cause behind the depletion of neurons is still unclear, but it is confirmed that beta-amyloid is the type of protein that has some sort of involvement in this process. Other associated risk factors for the patients of Alzheimer's are heredity and old age. In several cases, it has been reported that repeated head injuries can also lead to Alzheimer’s.
Symptoms of Alzheimer’s disease
Like any other disease, Alzheimer’s has also different symptoms. Let’s have a look at how the patients find it difficult to manage their everyday tasks.
​           Alzheimer's leads to a short term memory loss. It becomes difficult for patients to remember whatever happened recently.
A person suffering from Alzheimer's finds it problematic to express himself/herself. There is some difficulty faced while communicating verbally and that is due to inferior vocals. In the same manner, due to the improper response of different body parts, it results in poor coordination and movement.
The period of staying focused becomes very low. So a patient of Alzheimer's cannot manage different daily tasks easily.
When these symptoms start surfacing, it gets extremely frustrating for a patient to handle them. Though the subject is well aware of his/her problems but prefers to hide them for any reason. With time, these symptoms start getting bad. It ultimately leads to depression and anxiety. For close relatives of the patient, it is very difficult to see their loved one going through this ordeal.

Links:
https://www.beevenompowder.com/uploads/1/4/0/4/14046449/bee_venom_phospholipase_a2_ameliorates_alzheimer’s_disease_pathology_in_aβ_vaccination_treatment_without_inducing_neuro-inflammation_in_a_3xtg-ad_mouse_model.pdf
https://pubmed.ncbi.nlm.nih.gov/26772975/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501073/

​           Rheumatoid arthritis bee venom treatmenticture
Rheumatoid arthritis, or rheumatoid arthritis, is a chronic inflammation of the joints. In particular, the inflammation attacks cartilage, bones, tendons and arteries, but other organs, such as the skin and eyes, can also be attacked.
A characteristic of rheumatoid arthritis is that it is symmetrical. This means that if the right knee becomes inflamed, the same thing usually happens in the left knee too, roughly at the same time.
​Most commonly, the disease begins in the hands or in the feet. The capsule, which surrounds the joint, becomes inflamed. The affected person feels pain, and the ability to move is impaired. It can be harder to perform various everyday tasks, such as cutting bread.
​The symptoms of rheumatoid arthritis are symmetrical joint pain, stiffness and sore joints, especially in the morning. The joints swell, and often also heat. You also often suffer from an unexplained fatigue. Another feature is the small nodules, nodules, which form under the skin, especially on the elbows. Over time, the joints may become misaligned, as muscles and sensory skins end up in imbalance. This can cause the fingers to point outwards, towards the little finger. Most of those affected are in their 50s. What causes the disease is not known.
Hereditary factors seem to record, and in addition, it is known that smokers are more likely to suffer. There is no cure for rheumatoid arthritis, but the problems can be alleviated. It is important to move as much as possible, even when the pain is severe, as this helps with the problems. In addition, there are relieving drugs. How rheumatoid arthritis affects varies greatly from person to person. The disease is also various intensive during different periods, even for the same person.
The disease can be active for a longer or a shorter period, and then be less active. Such a period can be for several years. Therefore, there are those who suffer quite a bit from their illness for long periods, while others eventually get more and more pain, and become more tired and tired.
​           According to various scientific studies, bee venom powder is quite useful for rheumatoid arthritis. In this type of arthritis, a subject feels considerable pain due to inflammation around joints. Rheumatoid arthritis usually makes it difficult for a person, suffering from it, to easily move hands and knees as they swell and cause fatigue.
​           Arthritis also causes damage to arteries, tendons, bones, cartilage, and even eyes and skin. Though there is no particular treatment available for curing rheumatoid arthritis but there are a few effective natural remedies, like bee venom powder, that can help counter symptoms. Let's have a look at some clinical trials done by worldwide researchers concerning the effect of bee venom powder on subjects of arthritis.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1062163/
https://pubmed.ncbi.nlm.nih.gov/11207399/
https://pubmed.ncbi.nlm.nih.gov/474306/
https://ard.bmj.com/content/annrheumdis/32/5/466.full.pdf
https://pubmed.ncbi.nlm.nih.gov/30207564/
https://pubmed.ncbi.nlm.nih.gov/8403499/
https://pubmed.ncbi.nlm.nih.gov/16457792/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952296/

Astmatic bronchiole bee venom treatment.
Asthma and Its Expression
Asthma has affected a large population that includes adults and children. This disease is more common in the developed and industrialized world. It has been observed that during the past 50 years the cases of asthma have significantly gone up. Talking about the west, it can be said that nearly 10% of the general population suffers from asthma and among those affected, the percentage of boys is greater than of girls. ​
​What Is Asthma?
Asthma is a type of chronic inflammation that contracts muscles present around the trachea and leads to swelling of the mucous membrane. What does that mean? To be clear, asthma restricts the normal flow of air to lungs and that leads to shortness of breath, wheezing and coughing. Furthermore, the patient of asthma experiences sinus and nasal problems along with slimming in the chest. These are the basic symptoms of asthma.
What Are The Possible Triggers Of Asthma?
In several cases of asthma, these symptoms can get quite severe and if not dealt with on time, they can lead to severe consequences. It has to be determined yet that what causes asthma, but it is generally believed that certain chemicals, poor indoor environment, allergies, and air pollution can trigger asthma. Some people also have heredity asthma. It happens when one or both of the parents have symptoms of asthma. As a result, it is quite likely that their child will also develop symptoms of asthma at some point.
Who Suffers From Asthma?
Asthma can affect children too and the good thing is that symptoms can fade away with time. There are two different types of asthma: non-allergic asthma and allergic asthma. Adults usually face symptoms of non-allergic asthma, while children mostly suffer from allergic asthma.
It is also to be understood that allergic asthma can easily develop in those patients, who have some sort of hypersensitivity related to mites, animal fur, and pollen. When the body experiences any of these triggers the antibodies come into action that leads to an allergic reaction, which is called asthma.
On the other hand, non-allergic asthma is usually triggered by different respiratory infections, physical exertion, exhaust gases, tobacco smoke, perfume, drugs, cold air, smog, and dust.
A subject of asthma must judge the condition and make use of the latest and effective natural treatments like honey bee venom to control the symptoms. Any sort of treatment takes some time to deliver its effects so, patience is requested.

Links:
https://pubmed.ncbi.nlm.nih.gov/27669297/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693726/

Eczema – is an inflammatory disorder of the skin detected by itchy, red and dry patches of skin. It is most common in people who have a lot of allergic reactions. Principally, it is the response of skin to any sort of external irritants that lead to eczema.
​Beneficial Effects of Melittin on Ovalbumin-Induced Atopic Dermatitis in Mouse
​Introduction
AD (atopic dermatitis) is defined as an inflammatory skin disease, which is characterized by relapsable eczematous lesions and intense pruritus. This disease increases the risk for mental disorders, other immune system-related diseases, allergic rhinitis, asthma, and food allergy. AD arises due to flaws in the immunoglobulin E and epidermal barrier mediated sensitization to different environmental allergens. While the immune disorder arises due to an imbalance generated towards the T-helper-2 response.
​Even after a lengthy introspection of AD, the mechanism behind its evolution has not been clearly understood yet. But there are two different hypotheses, brought forward in this case. One states that primary disturbances, which already reside in the immunologic disorder, induce IgE mediated sensitization through epidermal barrier dysfunction due to local inflammation. Second states that, an intrinsic defect present in epithelial cells, leads to epidermal barrier dysfunction and immunological aspects arise due to barrier dysfunction.
Both of the hypothesis stated above, state some sort of defect in the immune system and epidermal barrier; it can be said that skin barrier function and immune system both interact closely. In the light of different clinical studies, bee venom therapy can help in targeting and improving the immune function and epidermal barrier at the same time.
Method and Results
AD was induced in the selected model mice. It was noticed that after receiving AD, their skin condition worsened as it leads to excoriation, erythema, and edema. These symptoms were controlled and removed once the selected group received melittin therapy. Melittin is an integral therapeutic constituent of bee venom.
H and E staining were carried out to determine inflammatory infiltration and thickness of dermis and epidermis. For this reason, 10 random fields were chosen. Thickness was measured perpendicularly and linearly to each specimen of skin. It was found that OVA stimulation enhanced inflammatory infiltration and that caused the skin of mouse to become thick. Whereas, the thickness of the skin in melittin induced group was quite thin than that of the OVA group.
Infiltration of the immune cells, like monocytes, dendritic cells, CD4+T helper cells, and macrophages, indicates a significant histopathological change in the AD. The macrophage-1 antigen also called the CD11b, expression was found on the surface of different leukocytes like macrophages, granulocytes, and monocytes. It was confirmed that OVA-induced infiltration of the immune cells and delivered the effect of melittin through immunohistochemical staining of CD11b and CD4. Expression of CD11b and CD4 in the upper skin was increased in the OVA group when compared with the NC group. OVA also induced expressions of CD11B and CD4 that were decreased in 100µk/kg-1 of the melittin group when compared with the OVA group.
Result
It can be said that OVA can play a prominent role in curtail AD type symptoms like thickening of dermis and epidermis, filaggrin deficiency, inflammatory infiltration, increased inflammatory mediators and exaggerated serum IgE. This study serves as evidence that melittin, under controlled concentration can lead to anti-inflammatory effects on the OVA-induced AD.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732199/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923312/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731956/
https://pubmed.ncbi.nlm.nih.gov/24294376/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843270/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240132/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131226/

What is Baculovirus?
We can describe a baculovirus as enveloped viruses, which infect the insect larvae mostly from Lepidoptera. If we look at their genetic structure, they are found to be circular in shape and double-stranded DNA molecules having the size of 80 to 180 kbp. These molecules are packed in the form of rod-shaped nucleocapsids having a length of 200-400nm and a diameter of 40-50nm.
There are different versions of baculovirus, but AcMNPV (Autographa californica multiple nucleopolyhedroviruses is the most common type; which is used in different clinical studies and utilization of biological processes.
How Does It Infect?
It infects in the same manner as other viruses but produces two different phenotypes during its infection cycle. ODV (Occlusion Derived Viruses) initiates infection right from the larvae midget. It is also known as the primary infection stage. After this, the viral progeny involves BV (Budded Viruses) that are responsible for carrying out the systematic infection.
Such types of virions differ in their mechanism of delivering an infection and that depends on their cell types; the ODV infects midgut epithelial cells up to 10,000 more than the BV. On the other hand, BV is 1000 times more efficient than ODV – when it comes to infecting cultured cells.
BV phenotype is generally responsible for mediating viral propagation in the cell culture. But most of the information available, related to the baculovirus infection mechanism, is based on different studies conducted on insect cells that are infected by BV.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865836/

Links:
https://pubmed.ncbi.nlm.nih.gov/26316200/
https://pubmed.ncbi.nlm.nih.gov/22109081/
https://pubmed.ncbi.nlm.nih.gov/21456063/
https://www.sciencedirect.com/science/article/abs/pii/S0304383509006831
https://www.sciencedirect.com/science/article/abs/pii/S0304383509006831
https://pubmed.ncbi.nlm.nih.gov/12782086/
https://pubmed.ncbi.nlm.nih.gov/16393467/
https://pubmed.ncbi.nlm.nih.gov/16485125/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946189/
https://pubmed.ncbi.nlm.nih.gov/18506888/
https://pubmed.ncbi.nlm.nih.gov/20195821/
https://pubmed.ncbi.nlm.nih.gov/20188461/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960167/
https://pubmed.ncbi.nlm.nih.gov/20821823/
https://pubmed.ncbi.nlm.nih.gov/19379183/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688974/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688974/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918564/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918564/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655938/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682937/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374791/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374791/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147578/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985046/

What Is Diabetes?
It is termed as a silent disease, which is caused due to high level of blood sugar. Glucose present in the blood is the main source of energy that comes from the different food items that we consume. The pancreas is responsible for producing insulin, a hormone that transfers glucose from the food to different cells of the body to be consumed as a source of energy.
When the pancreas does not produce adequate or any insulin or if the body doesn't use insulin properly then the level of glucose goes high, as it stays in the blood instead of reaching different cells. Having a high volume of glucose in the blood can lead to different problems. It is important to note here that, there is no allopathic medicine available that cures diabetes. But there are different measures that a diabetic person can take to control blood sugar levels and stay healthy.
3 Different types
There are three different types of diabetes and every condition needs to be taken seriously and addressed accordingly.
Type I – is known as juvenile diabetes, which takes place when the body loses its natural ability to produce insulin. Subjects of type I diabetes cannot survive without insulin; they take artificial insulin daily.
Type II – is the most common form of diabetes, which has a strong connection with obesity. It usually affects how the body makes use of insulin. In type I diabetes, the body does not produce insulin at all, but in this type, insulin is produced and what happens is that the cells lose their ability to respond properly.
Gestational diabetes – is common in women during the time of pregnancy, as the body does not remains sensitive to insulin at all. Symptoms of gestational diabetes disappear after the pregnancy is over. Not necessarily every woman would experience symptoms of gestational diabetes.
Fibrosis related diabetes and monogenic diabetes are also different types of diabetes that are not common.
Symptoms of Diabetes
Both Types I and Type II diabetes have their symptoms. Let's have a look at them.
Signs or Symptoms of Type I diabetes
Sudden weight loss – as the body does not get energy from food directly, it starts burning fat and muscle to produce energy. This eventually leads to weight loss; regardless of the manner, you are following your diet.
Vomiting and nausea – as the body starts burning fat, it leads to the production of ketones. They can develop to a dangerous extent and might lead to diabetic ketoacidosis – a life-threatening condition.
​Signs or Symptoms of Type II diabetes
ED (erectile dysfunction) in men
Poor vision
Tingling and numbness in hands and feet
Changes in the color of skin at groin, armpits, and neck
Weight gain
Yeast infection
Itchy skin around the groin area
Sores and cuts that heal very slowly.

Signs and symptoms of gestational diabetes
Feeling very thirsty
Urge to urinate goes high

What Sort Of Complications Can Surface Due To Diabetes?
A persistently high level of blood glucose can lead to the following problems.
Nerve damage
Dental disease
Eye problem
Kidney disease
Heart disease
Foot problems
How Is Diabetes Treated?
Subjects of type I and type II diabetes need to inhale or inject insulin so that their blood sugar level remains normal. There are different types of insulin available and they are categorized according to their effectiveness. Some patients use only one type of insulin while others might need a combination of different types of insulin to get the desired results. Too much insulin can lead to side effects like shaking, sweating and nausea due to extremely low levels of blood sugar.
           Effects of BCG, Lymphotoxin and Bee Venom on Insulitis and Development of IDDM in Non-Obese Diabetic Mice

​           Abstract
It was investigated in this experiment if BV, lymphotoxin or BCG can help prevent insulitis or development of diabetes in the NOD (non-obese mice). To conduct this experiment, a manifestation of diabetes and intensity of insulitis was evaluated in the 96 NOD and 24 ICR mice. The NOD mice group was randomly assigned to the control, BV, LT- and BCG-treated groups. LT was administered 3 times per week for a period of 4 to 10 weeks and BV was administered only once after 6 weeks.
           BV was administered in two weekly doses to a period of 4 to 10 weeks. It was observed that the symptoms of diabetes surfaced in the control group after 18 weeks, in the BV and LT treated group after 23 weeks and in BCG after 24 weeks.
Aggravating episodes of diabetes after 25 weeks in the control, BV, LT, and BCG treated NOD mice were 58%, 21%, 25%, and 17%, respectively. Severity and incidence of insulitis were reduced with the BV, LT and BCG treatment.
           Conclusion
Clinical studies conducted above clearly demonstrate that different types of BV treatment can help the management of insulin in subjects of diabetes. The experiments conducted did not show any sort of side effects. However, further experiments are required to determine the actual effective dose that can be beneficial for diabetes in humans.
Every conventional medicine has some sort of side effects that is why; researchers are trying to find a natural medicine that can be beneficial for diabetic people. Currently, bee venom is being studied and applied to diabetic patients to check their effectiveness.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547303/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054436/

Resistent Bacteria that Bee Venom can Kill
A bacterium consists of a single cell. A cell is defined as the biological and functional unit of a living being. It is also known as the building block of life. Cells are structured in a specific manner to help our body grow, repair and function properly.
​We humans are made up of millions of cells, but a bacteria only consists of one single cell. It is also a much simpler kind of cell than those found in our bodies that do not have eg. a core.
​Bacteria are very small, 0.01 - 0.001 mm long. You have to have a good microscope if you can see them at all. Bacteria multiply by dividing. Some manage to divide about every 20 minutes. This means that in one hour a bacterium has become 8, in two hours 64. Within two days these bacteria would be so many that they would fill the entire globe's volume! Now, thank goodness never happens that the bacteria can become so many because they must have food and heat and other things to be able to divide and the more they become, the less food it becomes and the division stops. Bacteria are neither plants nor animals but belong to their own group called "Prokaryotes".

Links:
https://pubmed.ncbi.nlm.nih.gov/27695631/
https://pubmed.ncbi.nlm.nih.gov/26771592/
https://www.beevenompowder.com/uploads/1/4/0/4/14046449/macropis_fulvipes_venom_component_macropin_exerts_its_antibacterial_and_anti-biofilm_properties_by_damaging_the_plasma_membranes_of_drug_resistant_bacteria.pdf

What Is Breast Cancer?
It is a type of cancer, which originates in the breast due to the uncontrolled growth of harmful cells. In the beginning, there is a small tumor present that can be detected physically, in the form of a lump or can be diagnosed through an x-ray.
But not all of the breast lumps are cancer-prone as most of them are benign. A non-cancerous tumor is just an abnormal growth that does not manifest outside of the breast and is certainly not life-threatening at all. It is highly recommended to detect and get checked any sort of changes or lumps observed in the breast by a professional health care expert, to determine if it's malignant or benign and what are the risks associated with it.
How Does It Begin And What Are Its Types?
Breast cancer can begin in any part of the breast. Possible areas of its origin are:
In ducts that supply milk to the nipple. This type of cancer is known as duct cancer.
In glands that produce milk. This type of cancer is known as lobular cancer.
In tissues of the breasts. They are known as lymphomas and sarcomas.
Less common types of breast cancers like angiosarcoma and phyllodes tumor.
Breast cancer can also be detected through mammogram screening. An early diagnosis can help initiate proper therapy before the cancer cells can play havoc.
​           How Is Breast Cancer Treated?Treatment for breast cancer helps in destroying the cancer responsible cells located within nearby tissues and the breast. Different treatment options are:
           Surgery
It is perhaps the most common treatment, known as a mastectomy, through which the whole breast is removed. In another process, tissues and tumors are removed and it is known as lumpectomy.
           Chemotherapy
Makes use of different drugs to eliminate cancer cells and the powerful medicines prescribed can lead to fatigue, hot flashes, early menopause, hair loss and nausea for a long period.
           Hormone therapy
In this type of treatment different drugs are used to control hormones that are responsible for aiding the growth of cancer responsible cells. Ovaries are also treated, through medication or surgery, to stop them from producing hormones. Side effects of these medicines can lead to vaginal dryness and hot flashes.
Targeted therapy Under this type of treatment, the natural immune system is strengthened to an extent that it can itself destroy the cancer cells. The medicines used, specifically target the cancer cells present in the breast.
A subject suffering from breast cancer can be given a combination of different treatments at the same time as hormone therapy, chemotherapy, radiation, and even surgery. A comprehensive regime is advised to get rid of the cancer cells completely.
It is important to mention here that all of the treatments, stated above, have severe side effects that can affect other organs of the body too. That is why medical professionals are looking for safe treatment options that do not disturb other functions of the body. In this case, bee venom is one of the most suitable options for treating cancer cells without damaging healthy cells.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238932/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777451/
https://www.beevenompowder.com/uploads/1/4/0/4/14046449/honeybee_venom_and_melittin_suppress_growth_factor_receptor_activation_in_her2-enriched_and_triple-negative_breast_cancer.pdf

Сervical cancer bee venom treatment
The other names for cervical cancer are collum cancer and cancer cervicus. After breast cancer, it is the second most common type of cancer among women. Cancer, if diagnosed at an early stage, can be controlled through a proper regime. Those women, who go for regular screening programs avoid the chances of becoming a victim of cancer to a great extent. And that is the reason that the ratio of cancer in women belonging to developed countries to those, who are from undeveloped countries is quite low.

Regular screening programs help in detecting the disease at an early stage. This leads to an on-time treatment. A screening program is also important because symptoms related to cancer can take a lot of time to surface so; it helps in making an early prediction. And if it is diagnosed late then till that time the disease might wreak havoc inside the body system. Sampling is done in a screening test to analyze any sort of cell changes.
These samples are tested thoroughly to determine the chances of any impending deadly disease. In the same manner, screening helps in detecting cervical cancer too. When done at an early stage the chances of recovery become quite satisfactory. On the other hand, if the growing cancer is not diagnosed at the right time, it can get very difficult for a woman to fight the growth of cervical cancer.
           The weight of the uterus is around 40 to 70 grams and is nearly the size of a pear. Outer walls of the uterus are composed of muscles that are nearly one centimeter thick, while the inner wall is made of a mucous membrane. During mensuration, the inner wall (mucous membrane) is responsible for the excretion made. Once the transitional stage is over, the uterus gets a little smaller in size due to shrinkage.
The cervix plays an important role inside the vagina. It is also another form of glandular mucosa that helps prevent dangerous infectious bacteria from getting inside the uterus. The border between the cervix and mucosa is known as the TZ (transformation zone). It is a very small area and any sort of human papillomavirus (HPV infections) can lead to cell changes and ultimately cancers. During the process of screening, cell samples are obtained from the TZ zone for colposcopy.
In a few cases, cervical cancer can be detected with the help of visible symptoms, but one must not solely rely on those symptoms. Sometimes these symptoms arise very late and the treatment gets complicated and challenging. So, regular screening is always recommended.
If you notice blood in your vomit or abnormal bleeding from the vagina during sexual intercourse consult a doctor right away. If left unattended you might experience bloody discharge from the vagina constantly.
Cervical cancer is most commonly transmitted through sexual contact and the virus responsible for its manifestation is known as human papillomavirus. Cervical cancer doesn’t initiate right away, as it requires certain conditions and changes. Any prolonged infection with a carcinogenic type of human papillomavirus is an essential prerequisite for developing into cervical cancer.
           According to various experts, it has been determined that there is a strong connection between sexual habits and the chances of cervical cancer in women. The obvious reasons are several partners, who can make a woman prone to this cancer during first pregnancy or first intercourse, excessive alcohol intake and tobacco consumption can also increase the chances of becoming a victim of cervical cancer.
Today cervical cancer has become quite common in women due to multiple sexual partners, an early sexual debut, unsafe pregnancy, and substandard oral contraceptives and even smoking.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208649/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466684/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862700/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332008/

In Hubei province, the epicentre of COVID-19 in China, the local beekeepers association conducted a survey of beekeepers. A total of 5115 beekeepers were surveyed from February 23 to March 8, including 723 in Wuhan, the outbreak epicentre of Hubei.
None of these beekeepers developed symptoms associated with COVID-19, and their health was totally normal. After that, we interviewed five apitherapists in Wuhan and followed 121 patients of their apitherapy clinic. These patients had received apitherapy from October 2019 to December 2019, and all the five bee apitherapists have the habit of self-apitherapy for their own health care (apitherapy means making use of bee venom from the honeybee's sting to treat or prevent certain diseases).
Without any protective measures, two of the five apitherapists were exposed to suspected COVID-19 cases and others were exposed to confirmed COVID-19 cases, but none of them were infected eventually. None of the 121 patients were infected by SARS-CoV-2, and three of them had close contact with immediate family members who were confirmed SARS-CoV-2 Infection cases. It might be supposed that beekeepers are less likely to be exposed to SARS-CoV-2 because they live in less densely populated rural areas. But the five apitherapists and their patients are from densely populated areas in Wuhan. These people have one thing in common: they develop a tolerance to bee sting.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190514/
https://www.researchgate.net/publication/310829208_Inhibitory_effects_of_bee_venom_and_its_components_against_viruses_in_vitro_and_in_vivo
https://www.sciencedirect.com/science/article/pii/S0041010120302245

What Is A Fungal Infection?
Fungal infections are quite common in humans and they occur when the invading fungus, hits a specific part of the body which, is too strong for the natural immune system to handle. But some types of fungi are not harmful to a human body and are a part of it. Apart from humans, fungi can also live in plants, water, soil, and even air.
As said above, there are two different types of fungi, the harmful fungi, and the helpful fungi. When our body is hit by harmful fungi, it gets difficult to get rid of it, as it can easily survive and cause some sort of infection. The most common types of infections are a yeast infection, ringworm, jock itch and athlete’s foot.
​           What Are The Symptoms Of Fungal Infection?
Symptoms vary from one type of fungal infection to another, but the common signs are:
Persistent itching on the infected area of skin
Changes in the appearance of skin
Cracking or peeling of skin
Redness and swelling of the skin
What Are The Risk Factors Associated With Fungal Infection?
Fungal infections are quite common in humans, though they are not life-threatening at all, but need to be diagnosed correctly and treated as soon as possible.
Any person, regardless of his age or gender, having a weak immune system, can become a victim of fungal invasion. In the same manner, if a person is consuming strong antibiotics for a long time then he can also become prone to a fungal infection.
          How Can Fungal Infections Be Treated?
There are several over the counter anti-fungal medicines available, but their heavy dosage and continuous usage can lead to different side effects like abdominal pain, weakness, loss of appetite, etc. Researchers are now focusing on testing different analyses that can control fungal infection and also protect the healthy cells from getting damaged. Bee venom is one of the favorite options, as it carries several anti-fungal components and has no adverse effects.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839892/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887751/

Can bee venom be treat HIV?
WHAT IS HIV?
Bee Venom HIV Treatment
Let's start from the beginning. HIV is a virus. The name is an abbreviation and means Human Immunodeficiency Virus. In a person infected with HIV, the virus attacks and destroys the white blood cells called T cells or "helper cells". These cells play an important role in our immune system (the body's defense against diseases). The HIV virus thus destroys the immune system. The virus rapidly multiplies in the body while the immune system is weakened. It usually takes a long time from the time of infection until the person becomes seriously ill.
The course is different among different individuals, but it takes on average about ten years. The only sure way to know that you have HIV is through a HIV test. Without treatment, the immune system continues to deteriorate and the number of "helper cells" drops to very low levels, then the immune system can no longer do its job. Without treatment, HIV is contagious and can be transmitted to others.
When the immune system is damaged, various diseases that the body can otherwise protect can, for example, a severe pneumonia called Pneumocystis, a type of skin cancer called Kaposi's sarcoma and repeated fungal infections of the airways and esophagus. AIDS means having one or more of these severe diseases because the damaged immune system cannot counteract them.
​Many people do not notice it at all, others may have symptoms similar to influenza or other viral infections, for example, fever, sore throat, swollen lymph nodes or skin rashes about 1 to 2 weeks after the infection. The only sure way to know if you have been infected with HIV is to test yourself. Testing is done with a blood sample.​
HIV belongs to a group of viruses called lentivirus, "slow viruses". It means that the virus can "sleep" in the body's cells for a short or long time to suddenly wake up and start attacking the body's immune system. It is the HIV virus's ability to "hide" and to convert to new variants that make it so difficult to cure HIV and to make a vaccine that works.
QUESTIONS ABOUT HIV & BEE VENOM
​​Why is it important to get checked regularly?
That is the reason, that doctors recommend timely checkups. It is also to be noted down that HIV is highly contagious and it can be easily transmitted to others. A weak immune system can offer no protection. For instance, if a person catches pneumocystis, which is a severe type of pneumonia, the remaining few white blood cells cannot confront them. In the same manner, a person suffering from HIV also becomes victim to other ailments like repeated infections of the esophagus, skin cancer, etc. When such types of multiple diseases, attack a person at one time the subject is known to be suffering from AIDS.
​When to worry?
If you experience skin rashes, swollen lymph nodes, sore throat, fever or influenza quite repeatedly, it’s about time that you go through a thorough series of tests – with HIV test being the top priority. Frequent relapse of these viral infections suggests that there is something seriously wrong with the natural defense system of the body.  
Why HIV is scary?
HIV is a slow-acting virus and that is why it is known as lentivirus. Such type of virus goes into hibernation, for a short or a long period, but can suddenly become active and attack white blood cells. HIV is one of the stealthiest types of a virus because it can easily hide and even convert to new alternatives. Thus, it makes it difficult to detect and cure HIV.
How does bee venom kill HIV cells?
Bee venom is loaded with several essential components that can deliver therapeutic effects. Melittin is one of the most prominent elements of honey bee venom. According to a study carried out by researchers Wickline SA, Ratner L, Campbell N, Jallouck AP, and Hood JL, it was established that bee venom certainly carries a positive effect that can finish the HIV. During the clinical study, high doses of melittin were used to strengthen the natural defense system and enable a molecular mechanism that will help detect and abolish HIV. It was observed that other cells of the body didn’t face any sort of side effects, like red blood cells.
To carry out the lab study, nanoparticles were used that were loaded with BV to destruct HIV. These nanoparticles contained the main ingredient of bee venom, melittin, which effectively killed the human immunodeficiency virus. During this experiment, no other cells received any sort of damage. This research was carried out at the Washington University School of Medicine.
Why bee venom is the popular remedy for HIV?
Bee venom has been used by South African and American doctors to treat patients suffering from HIV. Regular and controlled treatment of bee venom for several months helped in decreasing the intensity of HIV in the patients reported to be positive. When the virus starts dying it becomes difficult to even detect it through a proper HIV test and hence, the chance of transmitting it to others becomes zero.
Conventional medicines for treating HIV are very expensive and not only this, but they also have some serious side effects too. At one stage or another, the patient has to discontinue the expensive treatment. That is why it is important to establish some effective natural drugs that could address HIV. If we talk about the United States, the yearly cost for HIV treatment is around $30,000 (lower if an health insurance is available and take the cost) while the annual expense of bee venom treatment is only around $600.
What needs to be monitored?
Even while going through bee venom therapy for HIV, the patient needs to get checked for the viral load regularly. It is important to determine the progress and make bee venom dose adjustments accordingly. Another positive point of using bee venom for HIV is that it has little to nil side effects. This makes BV the best choice for treating HIV, as there is no trouble related to its charges and side effects.
Let us know about your own experiences of bee venom treatment for HIV or if you have any questions.

Links:
https://source.wustl.edu/2013/03/nanoparticles-loaded-with-bee-venom-kill-hiv/
https://pubmed.ncbi.nlm.nih.gov/22954649/
https://source.wustl.edu/2010/11/unconventional-idea-for-antiviral-contraceptive-gel-wins-gates-foundation-grant/

Help the body heal from inflammation with bee venom
Inflammation is the body's reaction to any sort of external attack, it can be any virus or an infection or an injury. Possible symptoms include pain, swelling, rising temperature, irritation, and redness. The symptoms are not limited to only these reactions, as they can manifest in several other different ways. Sometimes inflammation is caused due to an underlying chronic disease.
It is recommended to go through regular medical examinations to avoid any serious illness. You can even get your medical reports to get checked by a professional doctor and get proper advice. If you notice anything abnormal about your body do not ignore the symptoms. It is important to keep a check on what your body tells you. An integral part of living a healthy life is that you must listen to it.
So why do people experience redness, rise in temperature, swelling or irritation as symptoms of inflammation? Well, the obvious reason is that our bodies are designed to expel and counter any sort of external invaders. When any part of the body gets injured or infected, the whole body starts working on that specific target. Supply of blood and nutrients is fastened to that area and that is why inflammation occurs.
          Why do some people experience chronic pain or impaired functioning? Well, it happens as a result of our body's failure to maintain the strength of its natural defense system. All of the cells that are exposed to the brunt of any external effect emit chemicals that help to deal with the problem. That is why an affected area has more fluid around it and appears quite swollen.
           In the mean course, WBCs (white blood cells) become extremely active to protect the body and start dealing with the damage done. So if you think of inflammation as something unhealthy, you need to reconsider this thought of yours. As inflammation is a quick and apt response of your body to fight and get rid of the damage done. Certain inflammations tend to prolong, if not dealt with properly, and are known as chronic inflammations.
           It is also a matter of fact that, some several illnesses and diseases take birth from the complication of only a single chronic inflammation. Sometimes the symptoms are not that obvious and they remain hidden inside the body in the neurons, intestines, blood vessels and other areas of the body. If the disease is not diagnosed and treated on time, its consequences can have an extremely severe effect on other organs of the body.
Let's have a look at some diseases that show proper symptoms of inflammation:
-Certain cardiovascular diseases
-Different types of cancers
-Diabetes
-IBS
-Alzheimer
-Atherosclerosis
-MS
-Ulcerative Colitis
-Asthma
-Eczema
-Psoriasis
-Allergies
-Rheumatoid Arthritis
-Crohn’s Disease
Though, it cannot be declared that all of the above diseases show signs of inflammation at once. It might take several months for them to appear and till then, it might even get difficult to deal with the disease. So, always pay a regular visit to your health labs and get your blood samples tested for different reports. It will save you from any unwanted problems of health. You will also save time and money both.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273919/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549727/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017529/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1917405/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253680/

What Is Lateral Epicondylitis?
Lateral epicondylitis is also known as tennis elbow, which is a painful state of the elbow that arises due to its overuse. It mostly results due to racquet sports like tennis, but that's not it, as some several other activities and sports can lead to this condition.
It takes place due to inflammation, in any of the tendons that are connected with the outer forearm muscles. And it also happens because of a particular motion, repeated again and again at the same angle, which ultimately causes the tendons and muscles of the forearm to become damaged. After some time the elbow becomes tender and painful.
To treat tennis elbow there are several treatment options available. Mostly, physical therapists and primary doctors are involved in the process of rehabilitation. Surgeons are only required in acute cases of lateral epicondylitis.
General Anatomy of the Elbow
Elbow joint consists of three bones: humerus – the upper arm bone and radius and ulna – the two bones of the forearm. At the bottom of humerus, there are a few bony bumps called epicondyles while; the bony bump present on the lateral side of the elbow is known as the lateral epicondyle.
Various muscles, tendons, and ligaments are responsible for holding this elbow joint in one place. Lateral epicondylitis involves various tendons and muscles of the forearm. Our forearm muscles help in extending the wrist and fingers. Forearm tendons are called extensors that attach muscles to the bone and they are attached with lateral epicondyle. ECRB (Extensor Carpi Radialis Brevis) is the main tendon, which is directly involved in lateral epicondylitis.
What are the Causes of Tennis Elbow?
According to the recent studies, it has been revealed that tennis elbow mostly results due to damage lent to a specific muscle of the forearm. Extensor Carpi Radialis Brevis helps in stabilizing the wrist once the elbow is straightened. This happens when a tennis groundstroke is played. With time, ECRB becomes weak and that causes microscopic tears in the tendon and the long run results in pain and inflammation.
ECRB is also at an increased risk of getting damaged, due to its delicate position and role. When the elbow is bent and straightened too much, it causes the muscles to become weak due to constant rubbing against the bony bumps. So we can say that the tendon and muscles both become weak due to the ongoing wear and tear. Let us have a look at different factors that can cause lateral epicondylitis.
Different Activities
You will be surprised to know that there are other people also, apart from active athletes, who can suffer from this condition. Any activity in which forearm muscles are used vigorously and repetitively can lead to tennis elbow.
Carpenters, plumbers, and painters are mostly prone to this condition. Various studies have revealed that butchers, cooks and auto workers also develop symptoms of tennis elbow with time.
Age Factor
According to an observation, it has been found that most of the subjects of tennis elbow are between the age bracket of 30 to 50 years. But anyone can have these symptoms; who are exposed to the risk factors – repeated motion and overuse of the forearm muscles and tendons. Most of the tennis players, which have improper equipment and a poor stroke technique, belonging to any age group can develop this condition.
           What are the Symptoms of Lateral Epicondylitis?
Symptoms of this condition do not surface at once, as it develops gradually. Pain begins mildly and slowly gets worse with time. So any sort of pain, observed in this region, must not be neglected. Most common symptoms and signs of tennis elbow are:
Burning or pain in the outer elbow
Tenderness present on the outside of the elbow
Persistent aching and morning stiffness
A weak grip strength
Soreness in the outer forearm muscles
Pain in the outer elbow gets worse while holding an object.
All of the above symptoms indicate that active inflammation of tendinitis is present.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332005/

Liver injury healed with bee venom research
What Is Liver Injury?
Liver injury is also called liver laceration, which results due to any sort of trauma faced by the liver. It is also the most common type of abdominal injury. This can happen due to the penetration of any foreign object like a knife or a bullet or due to any massive impact like a car accident.
​The injury caused, can result in a liver hematoma or large tears – which go deep into the liver. A liver injury can become fatal if, severe bleeding occurs due to the damage done to the large blood vessels present in the liver. Any sort of bleeding that happens due to liver injury takes place inside the abdominal cavity. ​
​What are the symptoms of the liver injury?
Liver injury can be detected easily through the following symptoms:
-The subject will demonstrate symptoms of shock
-Skin color will become blue or pale
-Heart rate will go up and will lead to rapid breathing
-A Persistent abdominal pain
-Swelling of the abdomen (due to accumulation of blood)
How are liver injuries characterized?
There are different ways of characterizing liver injury.
They are stated below:
Medical professionals make use of ultrasonography or CT (computed tomography) scans to examine the liver injury.
Minor liver injuries take time, but they heal on their own – without any treatment. Only severe liver injuries require a surgical process.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257707/

Patients with lower respiratory tract infections are common in primary care. The most common is the cervical spine, that is, acute bronchitis, which is self-healing, but which can cause difficult coughing. Most serious is pneumonia, which is still a disease that can lead to death. Children <5 years have more pneumonia than adults, which is explained by the fact that they have more viral pneumonias. The incidence of bacterial pneumonias in the population, however, is the same as in adults, about 1 percent annually.
Respiratory tract infections are common in adults and adolescents. Acute bronchitis is one of the most prominent types of lung inflammations, which can heal itself but can lead to severe complications if not treated on time. Patients of acute bronchitis might have a nagging cough, sore throat, wheezing in chest, productive or nonproductive cough, chest tightness, shortness of breath and in case of severe inflammation fever, body aches and chills too.
​​           The most severe type of lung inflammation is pneumonia and it can lead to death too. As children have a weak immune system, they easily become a victim of this deadly disease. The most common symptoms of pneumonia are a pain in the chest while coughing or breathing, productive cough, general fatigue, shaking chills and sweating, vomiting or diarrhea, mental confusion, and high fever. The symptoms can vary from one person to another.
How to differentiate between pneumonia and bronchitis?
It can get difficult sometimes, to accurately diagnose a patient's condition when it comes to lung and respiratory tract inflammation. By the symptoms observed, it cannot be said that a person is suffering from pneumonia or acute bronchitis.
           To make a solid diagnosis, a CRP analysis is recommended. The C - reactive protein is a blood test that helps detect any sort of inflammation in the body. A blood sample is obtained to examine CRP that is produced by the liver. CRP is known as an active reactant and its level will rise by the inflammation. A high level of CRP will indicate some sort of serious infection.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885046/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167347/

Lyme borreliosis​ is a bacterial infection spread through ticks. It is believed that about one-third of the ticks carry bacteria that can cause Lyme disease. Approximately 1 tick bite of 150 gives a borrelia infection. The borrelia infection usually begins in the skin and if it is not treated there is a risk that the bacteria will move on to the nervous system or to the joints.
If the borrelia bacteria moves on to the nervous system you can get so-called neuroborreliosis, this infection can occur several months after the bite. Approximately one-sixth of all those receiving a borrelia infection receive neuroborreliosis. Common symptoms are pain, usually at night, which does not go away even if you are taking painkillers. It also happens that the face becomes partially paralyzed.
Neuroborreliosis is the most common bacterial cause of meningitis in both children and adults. Meningitis can cause symptoms such as fever, nausea, headache and neck stiffness. Immediate treatment is important as the consequences of neuroborreliosis can be serious with paralysis and brain effects.
The borrelia bacterium can also settle in the joints. Common symptoms are that you get joint and muscle pain and that the aches move in the body. Borrelia bacteria can also cause borrelia arthritis, a joint inflammation that causes different joints in the body to swell. Usually, the knee joint is affected and the swelling often passes by itself after a few days or weeks. The swelling can come back in different periods and often joints and muscles occur between these periods. In the worst case, joint inflammation can become chronic if it is not treated.



Links:
https://pubmed.ncbi.nlm.nih.gov/9233664/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745474/
https://www.researchgate.net/publication/330522489_A_Review_on_Bioactivities_of_Honey_Bee_Venom
https://www.longdom.org/proceedings/innovative-effects-of-bee-venom-therapy-on-lyme-disease-a-pioneering-study-52883.html

What is Lymphedema?
The lymphatic system plays an important role in the proper functioning of our immune system. There is fluid, called lymph, which circulates in the lymphatic system. And any sort of blockage in this system of circulation results in lymphedema.
So basically, lymphedema is the swelling that takes place in the arms or legs; it can affect a single arm or both arms and a single leg or both legs. This condition is most commonly found in the patients of cancer, whose lymph nodes are damaged while treating cancer cells. Any sort of disturbance in the system prevents proper drainage of lymph fluid and the buildup results in swelling.
There is no medicine available that cures lymphedema, but the symptoms can be managed through some care and a few medicines and on-time diagnosis.
What Are The Symptoms Of Lymphedema?
Symptoms and signs of lymphedema that occur in an affected leg or arm are:
Thickening and hardening of the skin (fibrosis)
Recurring infections
Discomfort and aching
A short-range of motion
The general feeling of tightness or heaviness
Swelling in leg or arm, including toes and fingers
Swelling due to lymphedema ranges from mild to extreme and these changes can make it very difficult to use that particular limb. In patients of cancer, lymphedema can surface after several months or years.
Types of Lymphedema
As you know that normally lymphedema takes place when the lymph vessels are unable to get rid of lymph fluid from an arm or leg. It has two types – primary and secondary.
Primary Lymphedema
It occurs on its own and it is an inherited, yet rare condition that results due to some problem in the development of lymph vessels. Primary lymphedema is caused due to:
Lymphedema Tarda – it occurs very rarely and normally begins after the age of 35 years.
Lymphedema Praecox – it occurs during pregnancy or around puberty, but it can also occur later.
Congenital Lymphedema – it occurs during infancy and disturbs the normal growth of lymph nodes, which later results in lymphedema.
​           Secondary Lymphedema
It occurs due to the presence of any other condition or disease.
This type of lymphedema is more common than the primary lymphedema.
Secondary lymphedema is caused due to:
Infection – any sort of parasites or infection of the lymph nodes can block the proper flow of lymph fluid. Lymphedema that arises due to infection is more common in subtropical and tropical regions than the developing countries.
Cancer – cancer cells can easily block the lymphatic system. It happens when the site of the tumor is close to a lymph vessel or a lymph node and its growth constricts the passage of lymph fluid. In the same manner, cancer treatment based on strong radiations can lead to inflammation and scarring of lymph nodes and lymph vessels. Surgery – any sort of injury lent to the lymph nodes during their removal can result in lymphedema.
What Are The Risk Factors?
After cancer, certain factors can increase the risk of getting lymphedema, like:
Psoriatic or rheumatoid arthritis
Obesity
Old age
How It Can Be Treated?
Apart from conventional medicines meant for controlling symptoms of lymphedema, currently bee venom therapy is also being used to treat lymphedema. The good thing is that BV therapy has no serious side effects and its results are extremely satisfactory.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129717/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009237/

bee venom therapy for MS
According to an estimate, it is believed that more than 2.5 million people, belonging to different areas of the globe, have multiple sclerosis. Abbreviated as MS, multiple sclerosis affects every person differently so; we can that symptoms vary greatly from one person to another.
What is multiple sclerosis?
It is a neurological disease, which permanently damages the cells of CNS (central nervous system), that is, the brain and the spinal cord. The central nervous system is responsible for controlling various functions of our body.
​One of the tasks of this system is to send signals to different organs to regulate a proper breathing mechanism. All of these functions are carried out with the help of neurons; we can also call them the transmitters of the central nervous system.
How is MS detected?
Multiple sclerosis takes a lot of time to affect these neurons; it can be a matter of several weeks or even months. MS can be diagnosed through brain MRI – a neurologist will recommend it after some basic examination.
​Apart from brain MRI some other responses like balance, sensations, reflexes, and neurological functions are judged to check the extent to which the CNS has been affected. Different types of tests are carried out with the help of a magnetic camera, to see what type of changes have been brought in the CNS due to MS.
Through this examination, it is not possible to detect tumors. To determine inflammation in the central nervous system, lumbar puncture samples are obtained. These samples are obtained right from the vertebrate with the help of a very thin needle. The lumbar puncture technique is superior to any other form of testing like fluid sample testing, spinal cord testing or magnetic camera examination. It helps in getting the right amount of information that can help diagnose multiple sclerosis.
​           The results obtained are evaluated by the medical history of the patient and the neurological tests made. It helps in getting a clear picture of the damage done and what type of treatment can be useful.
Bee Venom Extends Survival In Amyotrophic Lateral Sclerosis Models
ALS is known as amyotrophic lateral sclerosis, which is a serious disease that affects the central nervous system. This disease can be due to familial origin, death of motor neurons or even sporadic. If we discuss the genetic factors that are responsible for ALS then we can say, it is the mutant SOD1 that induces susceptibility of the motor neurons due to protein misfolding, neuroinflammation, inapt growth factor signaling, glutamate excitotoxicity, defective axonal transport, cytoskeletal abnormalities, oxidative damage, and defunct mitochondrial dysfunction.
BV (bee venom) is one of the most promising therapy drugs that have been used in different oriental medicines. There is ample evidence available, from different researches and examinations that suggest bee venom to be the most effective and safe option. Bee venom has anti-nociceptive and anti-inflammatory effects against an inflammatory reaction that is associated with different inflammatory diseases. This study was conducted to evaluate the effectiveness of bee venom when it comes to controlling motor neuron loss and activating microglial cells in the hSOD1 mice.
BV (bee venom) was administered, subcutaneously into, 98 days/ 14 weeks old, male hSOD1 mice at ST36 (Zusanli acupoint). This point was chosen because, in the light of preceding clinical trials, it has been established it mediates an anti-inflammatory effect.
To measure motor activity, the basic rotarod test was conducted while the Kaplan-Meier survival curve method was used to analyze survival statistics. The effect of bee venom therapy on anti-neuroinflammation of the hSOD1 mice was assessed with immunoreactions by TNF-α antibody and Iba as a microglia marker. Activation of caspase-3 proteins, MAPK (p38 MAP Kinase), Akt and ERK was examined through the western blotting method.
Bee venom treated hSOD1 mice demonstrated a significant decrease in the levels of phospho-p38 MAPK and microglia marker in the brain stream and spinal cord. It was also noticed that bee venom improved the medial survival and overall motor activity of the bee venom treated group by 139± days which is nearly 18% more than that of the control group that showed 117± days. Adding more, it was found that bee venom also suppressed the caspase-3 protein activity and controlled possible deficiencies of cristae morphology and mitochondrial structure in the lumbar spinal cord of the hSOD1 mice.
          Based on the findings of this lab examination, the research study indicates that bee venom can serve as a potential therapeutic agent which can control anti- neuroinflammatory effects in mice models of ALS.

Links:
https://pubmed.ncbi.nlm.nih.gov/16221950/
https://pubmed.ncbi.nlm.nih.gov/16541972/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832151/
https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-7-69
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1229070/
https://www.ldnscience.org/research/bee-venom-therapy-and-low-dose-naltrexone-for-treatment-of-multiple-sclerosis

What Are Microbes?
​           They are exceptionally small living things, which can only be seen through a powerful microscope – as it is impossible to see them with a naked eye. Microbes are present in air, soil, water and our bodies. There are millions of these tiny particles present on the inside and outside of our bodies.
​           A few microbes are harmful, while most of them are important for our general health. Explaining it further, we can say that good and a few bad microbes live together in our body and while killing the harmful ones the large population of healthy microbes also suffers.
What Are The Types Of Microbes?
Microbes have different life forms, as they dramatically have diverse characteristics and appearance.
The common types of microbes are:
Viruses
Protists
Fungi
Archaea
Bacteria
Our body is home to nearly all of the categories listed above.
What Do Harmful Microbes Do?
The percentage of harmful microbes is quite low and it is believed that only 1% of the harmful bacteria exist, which can invade our system and make us ill. Infectious diseases caused due to microbes are measles and flu, while they may contribute towards a non-infectious disease also like: coronary heart disease or some form of cancer. Microbes that can result in any type of the disease are known as pathogens.
           How Do The Microbes Act?
The pathogen is a microorganism that carries the potential to cause any sort of disease. An infection is caused due to the rapid onset and proliferation of pathogenic microbes in any individual. A disease becomes prominent when the responsible infection, results in any sort of damage to the vital system or functions. An infection doesn't have to be always going to result in disease.
How Do The Microbes Affect Us?
Microbes enter our bodies to cause an infection. They can enter our system through the following sites:
Through any sort of breaks on the surface of the skin (for example Clostridium tetani that result in tetanus)
Through urogenital tract (for example Escherichia coli that results in cystitis)
Through gastrointestinal tract (oral cavity of the mouth) (for example Vibrio cholera that results in cholera)
Through respiratory tract (nose or mouth) (for an example influenza virus that results in flu)
           Microbes after entering the body reach the target site and get attached to it so that the infection can begin. After that, they start to multiply in a very fast manner and absorb nutrients from the host (our body). It is interesting to tell here that, they avoid and survive attacks carried out by the immune system of a host.
How Are The Harmful Microbes Treated?
A harmful microbe can lend a lot of damage if it isn’t treated on time. The reason is that they multiply very quickly and can infect a large area within a short period. That is why strong medicines, like antibiotics, are prescribed to people suffering from different types of harmful microbes.
But each medicine has its side effects and one of them is that; along with the harmful microbes, they also damage the good or essential bacteria. That can affect a body's natural immune systems' strength to fight against any external harmful microbes.
For that reason, it is important to develop a natural therapeutic agent that can only target harmful microbes and protect useful bacteria. Honey bee venom is one of the best therapeutic agents which, if used in proper dose and cycle, can effectively kill the harmful microbes.
Conclusion
​Both of the clinical studies that have been discussed above indicate that bee venom or its components can help in controlling and eliminating harmful microbes. Bee venom is even effective on those microbes that are highly resistant to different antibiotics. These studies provide a platform for medical researchers to use bee venom for treating different types of microbes. Though, further studies are required that have a large sample base and include different components of bee venom and bee venom as a whole and different antibiotics. The antibiotic, if used, must be relevant to the type of microbe that is being studied. It will eventually make it easier for the health practitioners to recommend the patients, an exact dose and frequency of bee venom that can easily get rid of the harmful microbes.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043086/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043086/

What is neuropathic pain?
Neuropathic pain is caused due to any injury or disease that directly affects the somatosensory nervous system. It is a type of nerve pain and it is believed that nearly 7% of the total population suffers from different forms of neuropathic pain issues. Symptoms of neuropathic pain vary from one person to another – depending on the damage done to the nerve structure. In the beginning, a person feels an unpleasant pain, stinging, dullness, burning and swelling in the affected part of the body.
​In some subjects, a non-painful par-aesthesia might also occur. It is also known as projected pain, as it occurs on peripheral nerve innervation, and has no link with the area where nerves have been damaged directly. Disturbances related to proper fiber functioning are also observed. In the due course, skin becomes highly sensitive to touch, cold, heat and pain. 
When a person with this condition is touched, common pain is suddenly triggered and this condition is known as tactile allodynia. CRPS II (complex regional pain syndrome) is a type of neuropathic pain that begins due to nerve damage. In such cases, the pain spreads over a vast area of the body beyond the location of nerve damage.
Treatment
​Most of the conventional drugs, meant for treating neuropathic pains, are not that efficient. They also have adverse reactions, a low tolerance level and can affect the quality of life. That is why researchers are looking at bee venom as it's know for it's both anti-inflammatory effect and pain relieving properties.
Two Types of Neuropathic Pain
There are two different types of neuropathic pains: central neuropathic pain and peripheral neuropathic pain. Central neuropathic pain arises due to any sort of disorder or damage received by the spinal cord or brain. And peripheral neuropathic pain is caused due to disturbance or injury faced by any other part of the sensory nervous system.
According to different epidemiological studies, it has been concluded that subjects of neuropathic pain do not get the right treatment. The main reason is that the diagnostic done is poor and hence the treatment prescribed is ineffective. So that tells there is insufficient knowledge available that could help patients to recover from symptoms of neuropathic pain.
Patients suffering from cancer, back pain, and diabetes have symptoms of neuropathic pain. Neuropathic pain leads to different complications if not treated on time. There is a need for developing better diagnostic procedures and then prescribing a proper treatment to the patients of neuropathic pain. Neuropathic pain can further lead to impaired physical functions, disturbed sleep, and depression. It is also very difficult for the other family members to manage the patient due to financial and medical issues.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332002/
https://pubmed.ncbi.nlm.nih.gov/25091565/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773786/
https://ard.bmj.com/content/annrheumdis/32/5/466.full.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705976/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676995/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744126/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516921/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563768/
https://pubmed.ncbi.nlm.nih.gov/25366818/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761090/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705966/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373861/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747437/

What Is Obesity?
It is a medical condition, which arises when a person has additional weight in the form of stored fat that can affect overall health. Obesity can be termed as a complex disease, as it can complicate into different issues like certain cancers, high blood pressure, diabetes, and heart disease. So it is more than just a cosmetic factor.
For many people, it is very difficult to avoid obesity and that’s due to an inherited factor combined with poor diet and an inactive lifestyle. For other subjects of obesity, without any hereditary reason, behavior changes increased physical activity, dietary changes and certain medications can help lose weight. Weight loss regime along with prescription medicines are usually meant for people having chronic obesity.
How Is Obesity Detected?
Normally, the BMI tool is used to assess the weight of a person according to sex, age, weight, and height. BMI index above 25 indicates that a person is overweight, while above 30 indicates that a person is obese.
A person's body shape and weight are further determined through the distribution of fat, waist to height and waist to hip size ratio. An obese person can also develop arthritis and metabolic syndrome. Under metabolic syndrome come different issues like type II diabetes and high blood pressure.
​           What Factors Lead To Obesity?Several factors can lead to obesity in men and women and they are stated below:
Consuming additional calories for a long period
Leading an inactive lifestyle
Not getting enough sleep
Presence of endocrine disruptors
Weight gain due to any certain medication
Obesity gene
An obese person must consult a doctor and go through a proper body examination before exercising or using any sort of medicine.
How Is Obesity Treated?
A professional doctor will conduct some tests after a physical examination. It is important to take into regard the health history of an obese person and then make an appropriate diagnosis. This will eventually make the treatment process a lot easier and effective, in the long run.
Many doctors recommend strong medicines to obese people, which help with weight loss, but damage other organs like kidneys and liver. These medicines work unnaturally to help a person get rid of excess fat. What an obese person needs to do is; start exercising daily and have a healthy diet and then choose a natural medicine that will help get rid of accumulated fat.
Bee venom contains various essential components that are useful in different medical conditions. It has been observed that bee venom with a proper dose regime can help get rid of obesity. And the best part is that, when administered carefully, there are no side effects of this treatment.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793096/

Bee venom for osteoarthritis
What is osteoarthritis?
It is a disease that primarily targets the joint cartilage and as a result, makes the entire joint weak. A healthy joint, which is not affected by osteoarthritis, has a proper ratio between its overall structure and degradation of cartilage.
​But in the subjects of osteoarthritis, there is a sheer imbalance between the cartilage degradation and maintenance or buildup. Or we can also say that the process of degradation of cartilage becomes very fast and that leads to further complications. Several steps can be taken to help improve the symptoms of osteoarthritis.
What causes osteoarthritis?
It has not been established until now that what leads to osteoarthritis. But different factors further strengthen the risk of catching this disease and they are:
Abnormal use of the joint
Old age
Any sort of joint trauma/injury
Being overweight/obese
Having other medical issues related to bones or cartilage-like rheumatoid arthritis
Heredity reasons​
How is osteoarthritis diagnosed?
There is good news and that is: osteoarthritis can be diagnosed through different medical examinations and that makes it easy for a doctor to control the symptoms. It is a general misconception in people that only an x-ray can be conducted to diagnose osteoarthritis. Or joint pain will indicate that a person is suffering from osteoarthritis. But in reality, osteoarthritis doesn't take place in a day or two, as it is a lengthy process of degeneration of cartilage. It can take several years for cartilage to show the damage that can further lead to other symptoms.
Till the time a person observes these symptoms, the situation tends to get pretty bad. What doctors recommend is that a person must make regular trips to an occupational therapist or a physiotherapist and undergo different physical examinations to determine the condition of joints. An early diagnosis can help control the process of cartilage damage and save a person from chronic joint pain.
What are the other factors that put people at risk of catching osteoarthritis?
Osteoarthritis is not about only wear and tear of a joint, as the recent studies, conducted about this disease, reveal some alarming developments. Osteoarthritis has been linked to certain environmental factors and a person’s diet too.
It is believed that excessive intake of sugar raises the level of cytoklines and that causes inflammation, which can be dangerous for a person having a weak joint. In the same manner lectin, a type of protein, found in legumes, cereals, nuts, and even milk can lead to osteoarthritis. According to Steven Grundy, lectins are an active part of the leaky gut syndrome that can easily attack joints and blood vessels.
To further investigate the effect of osteoarthritis, bones structures of people belonging to the 19th and 20th centuries were compared from different perspectives like age, weight, and gender. The study revealed that osteoarthritis had worsened in the people of the 20th century and there were links found indicating damage done by air pollution and chemical emissions. This tells that the deteriorating air quality has affected the general health of people to an alarming extent.

Links:
https://pubmed.ncbi.nlm.nih.gov/11527062/
https://europepmc.org/article/PMC/1062163
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331948/
https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-7-69

Bee venom for ovarian cancer
The female reproductive gland is known as an ovary and as there are two glands present hence, they are known as ovaries. Ovaries are responsible for producing eggs and female hormones like progesterone and estrogen. Ovarian cancer surfaces when the abnormal cells located in ovaries start multiplying and their production gets out of control. It eventually leads to a tumor. Ovarian cancer is also a collective name given to multiple cancers that originate from, in and around the ovaries.
​What are the types of ovarian cancer?
Most of the cases of ovarian cancer are reported to occur in women aged between 60 to 70 years old. This type of cancer is divided into two different categories: epithelial cancer and non-epithelial cancer.
Cancer that grows in the fallopian tube, the peritoneum and the outer surface of the ovary is called epithelial cancer. While cancer that originates from the inside of an ovary is called non-epithelial cancer. There is another type of tumor called borderline tumor, it exists between the benign and malignant borderline. This tumor results due to changes occurring in the number of cells, but it is not called cancer.
What are the reasons that cause ovarian cancer?
Ovarian cancer is caused due to different risk factors that are associated with: multiple ovulation periods, few pregnancies, infertility, late menopause, and early menopause. In the same manner, different natural factors protect from ovarian cancer like having several pregnancies, making proper use of contraceptives, breastfeeding and undergoing sterilization or ovarian removal. Lifestyle factors like having a normal BMI index and an active lifestyle also helps in getting rid of the risk of catching ovarian cancer. There are also hereditary variants that lead to ovarian cancer.
Elaborating further, BRCA1 and BRCA2 mutation most commonly develops a risk for women to become a victim of ovarian cancer or breast cancer. On the other hand, inherited mutations, which have any sort of link to other forms of cancer, in both women and men, can also indicate an increased risk of catching ovarian cancer. It is to be noted that most of the women, who are more than 50 years of age are diagnosed with this type of cancer.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017821/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522379/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487985/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192441/
https://pubmed.ncbi.nlm.nih.gov/22027265/

What is Parvovirus B19?
It is also called B19V, which is a single-stranded virus belonging to the family Parvoviridae. The type B19 only affects humans and the symptoms differ according to overall health and age. It has been found that 2 out of 10 people are infected with this virus and it is not even necessary that they would have any apparent symptoms.
What are the Symptoms of Parvovirus?
It most commonly leads to fifth disease – mild rashes (observed mostly in children). Common symptoms of this virus are:
Severe anemia
Swollen or painful joints
Redness of skin
How Is It Transmitted?
Usually, it spreads through the respiratory secretions of an infected person like nasal mucus, sputum, and saliva. It can also spread through infected blood products.
How Is It Diagnosed?
Normally a blood test sample is obtained from a possible subject to determine if the virus has been activated or not.
           How It Can Be Prevented?
Currently, there is no allopathic medicine or vaccine available that can help prevent this virus. But the chances of being affected or affecting others, with parvovirus B19, can be contained through the following measures:
Covering nose and mouth completely while sneezing or coughing
Washing hands thoroughly with a disinfectant soap and water
Resting and staying at home while sick
Avoiding close contact with those who are suffering from this virus
           Now, let’s have a look at the Bocavirus.
What is Bocavirus?
It is also called human bocavirus or HBoV, which is a non-enveloped and a single-stranded virus belonging to the family Parvoviridae. It is a newly discovered virus that affects children mostly. HBoV is also termed as 'an emerging viral pathogen', due to the reason that it is associated with other infections. It has to be yet proven that, if this virus manifests on its own or is caused due to other viruses or exists in parallel with other viruses.
What are the Symptoms of Bocavirus?
The following are the signs and symptoms associated with Bocavirus.
High fever
Persistent coughing
Acute respiratory tract infection
Rhinorrhea
Cyanosis
Vomiting
Diarrhea
Children having these symptoms can get very ill and often require hospitalization.
How Is It Transmitted?
According to the scientific findings, it can be declared that bocavirus is mostly spread through respiratory secretions. Traces of this virus can be detected from blood samples and stools. It is most commonly found in young children, who often remain sick.
How Is It Diagnosed?
Normally a blood test sample is obtained from a possible subject to determine if the virus has been activated or not.
How It Can Be Prevented?
Bocavirus strains are not solely responsible for the symptoms stated above. And there is no vaccine currently available that helps in controlling this virus. General hygiene and protection are recommended to prevent this virus from spreading and being transmitted.
How Can Parvovirus and Bocavirus Be Treated?
Conventional medicines that are being used to treat symptoms of these viruses are not effective or have some sort of adverse effects. Researchers are currently making use of natural therapies like honey bee venom to treat Parvovirus and Bocavirus. 

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182432/

Parkinson & Bee Venom
What is Parkinson’s disease?
We can define Parkinson’s disease, as a neurological disorder that affects elderly people – most subjects of this disease are 50 years old or even above. Parkinson’s is common in both men and women, but it has been observed that the ratio of men receiving this disease is slightly greater than that of women.
​A person suffering from Parkinson’s disease experiences the slow death of neurotransmitter dopamine – produced by the neurons. Eventually, the level of dopamine starts falling in the brain. What does dopamine do? Dopamine is responsible for transmitting signals to different parts of the body. If the level of dopamine drops, it leads to poor signals and as a result, the response gets slow and somebody parts even start shaking.
           What are the symptoms of Parkinson’s disease?
Symptoms start appearing, as soon as the dopamine generating neurons die. It is interesting to note here that, there is no effective medicine that can cure this disease. Medicines available just help in controlling the symptoms associated with Parkinson’s. It is called a progressive disease; it means that the symptoms tend to get worse with time.
This disease develops at a very slow pace and as said the symptoms take ample time to surface. When the movement-related issues start, it means that the level of dopamine has dropped dangerously. A person can have Parkinson’s for years and never know about it.
How does Parkinson’s progress?
In the beginning, it is only the dopamine system, which is affected greatly. As the disease continues to progress, other signal bodies like serotonin and acetylcholine also start diminishing. When the level of these two chemicals starts to drop, it leads to dementia, poor sleep rhythm, depression, anxiety, stress, impaired learning ability, and wakefulness.
The autonomic nervous system is also affected by Parkinson's and that can lead to excessive sweating, gastrointestinal and bladder problems, and disturbed blood pressure. This disease doesn't need to progress in the same manner for every other subject of Parkinson's. Symptoms can vary greatly and several factors can aggravate the symptoms like having a chronic disease or illness along with Parkinson's.
Can Parkinson’s be reversed?
As said earlier that there is no medical cure available for this disease hence, it is difficult to manage it. But different modern treatments can increase the level of dopamine in the brain and thus lessen the severity of associated symptoms. It is also understood that the initial symptoms take several years to appear – the premotor symptoms – and a person needs to be well aware of them. And they are constant depression, impaired activity, constipation, REM sleep disorder and an impaired sense of smell.

Links:
https://www.mysciencework.com/omniscience/bee-venom-a-treatment-for-parkinson-s-disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942057/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630120/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462482/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213536/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004420/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973312/

Psoriasis – like eczema it is another inflammatory disease of the skin. Subjects of psoriasis have flaky patches and redness visible on their skin. It happens when the immune system starts attacking the healthy cells of our skin due to any sort of immune disorder.
Honey and Bee Venom in Dermatology:
A Novel Possible Alternative or Complementary Therapy for Psoriasis Vulgaris
Introduction
Apis mellifera is a complex form of different carbohydrates gathered from different plants and flowers and modified by the honey bee. Honey bee venom, for this reason, has several therapeutic effects like anti-oxidant, anti-viral, anti-bacterial and anti-inflammatory properties. These characteristics are linked with high acidity, peroxide content and osmotic effect.
Various treatment options of these bee venom components have been examined in different clinical studies. It has also been found that an undiluted version of honey bee prevents the growth of different organisms like Candida Albicans and staphylococcus. Jeddar et all. made a statement that pure honey at 40% concentration acted as a bactericidal agent to the gram-positive and gram-negative bacteria.
Discussion
Honey helps with healing wounds, as in ancient times it was used to dress wounds. Both honey and bee venom has been used in different ailments of skin like dermatitis, eczemas, and psoriasis. Now the modern clinical studies also confirm that honey is extremely effective for treating pressure and venous ulcers.
           BVA (bee venom acupuncture) is, a herbal acupuncture method, performed with a diluted version of bee venom. It is used to treat different types of illnesses and diseases. BVA is administered into ashi points and acupoints of the body. According to lab tests, it has been confirmed that bee venom acupuncture administration leads to several clinical benefits.
Psoriasis is one of the most common skin ailments, which can get quite chronic. It is generally characterized by scaling and erythematous plaques. Etiopathogenesis of this disease is not still clear, but it has been studied that IL2 production and Th2 cell activity is brought down during psoriasis.
An elevated level of βmRNA and IL1α was found in keratinocytes that were cultured from the psoriatic treatment of the psoriasis Vulgaris – it has a similar pathway with the RA. Several controlled studies and multi-centers are required to have a better understanding of this hypothesis. And in the light of that establish that bee venom can help control psoriasis Vulgaris.
Conclusion
Honey bee venom has several components that need to be explored and used for different skin issues. It is one of the best gifts of Mother Nature – and can become an integral part of different skin medicines. The cellular and molecular mechanism of honey bee venom needs to be studied carefully, which carries strong antioxidant properties. Bee venom can also be used with convention medicines to deal with different diseases of the skin.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264310/
https://www.netjournals.org/pdf/IRJMMS/2013/1/12-012.pdf

What Is Systematic Sclerosis?
​We can define it as a rare but chronic disease, caused due to unknown reasons, which are characterized by vascular abnormalities and diffuse fibrosis of internal organs, joints and skin. Its diagnosis can be made on a clinical level only, through laboratory tests. Following a specific treatment after diagnosis is difficult, as each conventional medicine has its complications.
​           What Are The Types Of Systematic Sclerosis?
It is classified into three different categories:

1.) Limited systematic sclerosis – is also known as CREST syndrome. In this type of SSc, subjects experience tightening of the skin over the face and near the knees and elbows. The patient might also experience gastroesophageal reflux. It progresses slowly, but can later become complicated due to pulmonary hypertension.
 2.) Generalized systematic sclerosis – patients develop GI complications and Raynaud phenomenon along with diffuse skin movement. It is a fast-progressing disease, which can later complicate scleroderma and interstitial lung disease.
 3.) Systematic sclerosis sine scleroderma – does not lead to any sort of skin tightening symptoms, but patients experience the visceral manifestation of this disease and systematic sclerosis antibodies.
What Are The Symptoms Of Systematic Sclerosis?
Different symptoms or signs of this disease start surfacing after episodes of Raynaud phenomenon – develops a few weeks before fibrosis. Raynaud phenomenon causes fingers and toes of a patient to turn blue or white in response to stress or temperature changes. It is due to the reason that tiny blood vessels are damaged and their ability to carry blood to different extremities is affected. Other symptoms include:
Puffy and swollen hands or feet
Thickening and hardening of the skin (starts from the fingers first)
Ulcers on fingers
Painful bumps right under the skin
Clusters of blood vessels under the skin that appear enlarged
Pain, numbness, and stiffness in different joints
Red spots on chest and face
Muscular weakness
How Does Systematic Sclerosis Effect Internally?
SSc leads to fibrosis, which can badly damage internal organs too and in some cases, complete failure or impairment of affected organs can take place. Fibrosis can affect kidneys, lungs, heart and the esophagus easily. Also, the disturbance caused to internal organs can further lead to diarrhea, shortness of breath, impairment of intestinal muscles, kidney problems, hypertension, dysphagia, and heartburn.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310600/
https://www.researchgate.net/publication/12026516_Bee_Venom_Pretreatment_Has_Both_an_Antinociceptive_and_Anti-Inflammatory_Effect_on_Carrageenan-Induced_Inflammation

What Is Rheumatoid Arthritis?
We can define rheumatoid arthritis, as a condition during which the joint remains in a constant state of inflammation. Rheumatoid arthritis is mostly found in older men and women and rarely affects young men and women. The underlying cause of rheumatoid arthritis is still unclear but it falls under the category of autoimmune diseases. An autoimmune disease is one in which the immune system of the body breaks down and starts attacking its tissues. We cannot say that rheumatoid arthritis is a hereditary disease, but in some cases, it can be due to hereditary reasons. ​
​What Factors Can Lead To Or Aggravate Rheumatoid Arthritis?
According to health experts, smoking is one of the severest external risk factors that can cause rheumatoid arthritis. And for women, who are obese, it is very easy to become a victim of this disease. There are also certain mental factors, joint injuries, and infections that can aggravate or initiate arthritis. There is also a role of poor diet and an inactive lifestyle when it comes to exploring factors that can cause rheumatoid arthritis.
How Is Rheumatoid Arthritis Diagnosed?
For some people, this disease can bring forward multiple symptoms. Those patients who have multiple joint issues can get checked for rheumatoid factors through their blood samples. This will help in analyzing the extent to which different joints can receive damage shortly. A joint affected by rheumatoid arthritis will have swelling and thickness and fresh blood vessels around it.
Clinical Randomized Study of Bee-Sting Therapy for Rheumatoid Arthritis
Objective
The main purpose of this clinical study was to examine the therapeutic effect of bee venom for treating RA (rheumatoid arthritis). For this study, a special regime was adopted to determine the efficiency of different bee venom components.
Method
100 patients of rheumatoid arthritis were chosen for this examination and they were divided into two different groups, each group had 50 patients. The first group was the bee venom group and the second group was the control group. Patients belonging to bee venom group were administered bee venom of ashi-points and Meloxicam (Mobic, 7.5mg, b. i. d.), Sulfasalazine (0.5g, t. i.d.) and Methotrexate (MTX, 7.5mg/w). And the second group was orally administered Meloxicam (Mobic, 7.5mg, b. i. d.), Sulfasalazine (0.5g, t. i.d.) and Methotrexate (MTX, 7.5mg/w).
In the first group, ashi-points were chosen according to the part affected by rheumatoid arthritis and were defined as the main acupoints. They were further augmented with additional acupoints by syndrome differentiation. This treatment was based on a period of 3 months in total and the dose was administered after a gap of one day. Only a single dose was given.
Result
After the period of experimental treatment came to an end, various comparisons were carried out. It was found that the scores of morning stiff duration, a 15-meter walk, grasp force, joint swelling number, pressing pain, joint activity, and joint swelling degree after the bee venom treatment had significantly improved. This was noticed in the medication group and bee venom group both (P<0.05, 0.01). A further comparison between these groups revealed that the scores of morning stiffness duration, joint swelling number, pressing pain and joint swelling and doses of Mobic and MTX administered, were all low when compared with the medication group (P<0.05, 0.01). Grasp force was also higher in the bee venom group than of the medication group (P<0.05). In the end, the relapse rate of the BV group was significantly lower than that of the medication group and stood at P<0.05, 12% vs. 32%.
Decision
It can be said that a combined effect of medication and bee venom is far effective than that of simple medication. When used with bee venom the number of other medicines can be brought down and hence fewer side effects. Bee venom can help in dealing with rheumatoid arthritis and control the relapse rate.

Links:
https://pubmed.ncbi.nlm.nih.gov/18807725/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225238/
https://pubmed.ncbi.nlm.nih.gov/12031688/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010843/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2445826/

What Is A Wilting Disorder?
According to Traditional Korean Medicine, it is also known as Wei-Syndrome. In this condition, there is an abnormal paralysis and weakness of the lower and upper extremities, experienced by the subject.
What Are Its Symptoms?
Just like any other disease, infection or illness, the wilting disorder has different symptoms associated with it.
Each symptom depicts the progression of this condition. Most common signs, of wilting disorder, are as follows:
Loss of muscle mass in the paralyzed and weakened areas
The slow or total disappearance of reflexes
A noticeable decrease in muscle strength of the affected limbs
Dry skin with a pale appearance
Wrinkling of skin
General fatigue

What Causes Wilting Disorder?
As defined by Traditional Korean Medicine, there are different factors responsible for this condition.
Some are external while others are internal causes. Let us have a look at them.
-External factors
-Due to any trauma
-Due to overuse of any part of the body
-Neurologic dysfunction that leads to chronic fever
-Any disease with a long morbidity period
Internal factors
An inactive or unhealthy lifestyle that leads to slow metabolism and a weakened immune system
Malfunctioning of kidneys, lungs, spleen, heart or liver
All of the above factors damage soft tissues, joints, and bones. If left untreated, these symptoms can get worse with time.
How Is Wilting Disorder Treated?
Several medical studies have been conducted, related to the treatment of Wilting disorder, but every other study that includes conventional or allopathic medicines has demonstrated adverse effects. It is due to the strong dose cycle that further complicates the condition for a subject of the wilting disorder. Currently, The Traditional Korean Medicine clinical studies focus on using a natural component – honeybee venom – for treating the wilting disorder without any side effects.

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260545/

In a study after 12 weeks of treatment all participants significantly improved with the bee venom treatment. The effect was notable improvements in wrinkle. This study confirms the excellent effect of bee venom to reduce wrinkles. Although the exact mechanism by which bee venom exerts its anti-wrinkle effects is not knows.
​The results also shows that bee venom plays an important role in the improvement of skin wrinkles. That is why bee venom in the cosmetic industry as an anti-wrinkle agent. Studies also show that treating skin with cosmetics containing bee venom could be safe, because the irritation potential of bee venom is negligible. With research backing up the claims that bee venom can reduce wrinkles, we will likely see an increase in cosmetic products containing bee venom. The bee venom is not only useful for wrinkles on the skin, it can help with several other skin problems. ​

Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598227/

The products and claims made about specific products on or through this site have not been evaluated by the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease.
​This site is not intended to provide diagnosis, treatment or medical advice. Products, services, information and other content provided on this site, including information that may be provided on this Site directly or by linking to third-party websites are provided for informational purposes only. Please consult with a physician or other healthcare professional regarding any medical or health-related diagnosis or treatment options.
Information provided on this site and linked websites, including information relating to medical and health conditions, treatments and products may be provided in summary form. Information on this site including any product label or packaging should not be considered as a substitute for advice from a healthcare professional. This site does not recommend self-management of health issues. Information on this Site is not comprehensive and does not cover all diseases, ailments, physical conditions or their treatment. Contact your healthcare professional promptly should you have any health-related questions. Never disregard or delay medical advice based upon the information you may have read on this site.
You should not use the information or services on this site to diagnose or treat any health issues or for prescription of any medication or other treatment. You should always consult with your healthcare professional and read the information provided by the product manufacturer and any product label or packaging, before using any medication, nutritional, herbal or homeopathic product or before beginning any exercise or diet program or starting any treatment for a health issue. Individuals are different and may react differently to different products. You should consult your physician about interactions between medications you are taking and nutritional supplements. Comments made in any forums on this site by employees or site users are strictly their own personal views made in their own personal capacity and are not claims made by us or do they represent the position or view of Api Nature. Product ratings by any current or previous employees or site users are strictly their own personal views made in their own personal capacity and are not intended as a substitute for appropriate medical care or advice from a healthcare professional.
Always check the product label or packaging before using any product. If there are discrepancies, customers should follow the information provided on the product label or packaging. You should contact the manufacturer directly for clarification as to product labeling and packaging details and recommended use.
Api Nature is not liable for any information provided on this site about recommendations regarding supplements for any health purposes. The products or claims made about specific nutrients or products have not been evaluated by the Food and Drug Administration. Dietary products are not intended to treat, prevent or cure disease. Consult with a healthcare professional before starting any diet, supplement or exercise program. Bee Venom Powder makes no guarantee or warranty for any products or services sold.
​Api Nature is not responsible for any damages for information or services provided even if Bee Venom Powder has been advised of the possibility of damages.